A key limiting factor for dietary use of single cell protein is the high mass fraction of nucleic acid, which limits daily consumption due to uric acid production during metabolism. High rates of RNA synthesis are unfortunately necessary for high protein productivity.
The paper notes:
>It is important to note that MP products often contain elevated levels of nucleic acids, constituting ~8% of the dry weight [17], which necessitates consideration when assessing their suitability for human consumption. To address this, a heat treatment process is employed at the end of fermentation that reduces the nucleic acid content in the fermented biomass to below 0.75/100 g, while simultaneously deactivating protease activity and F. venenatum biomass. However, this procedure has been observed to induce cell membrane leakage and a substantial loss of biomass, as evidenced in the Quorn production process [17], which also utilizes F. venenatum as the MP producer. Our experimental trials have encountered similar challenges, achieving a biomass yield of merely ~35%, and observed that heating process increased the relative protein and chitin content (Figure 2D,E), which may be related to the effect of membrane leakage, while the intracellular protein of the FCPD engineered strain was less likely to be lost to the extracellular. Thus, concentrating the fermentation broth to enhance protein and amino acids content in successive steps to produce a highly nutritious water-soluble fertilizer appears to be an effective strategy for adding value to the process (Figure 1).
The challenges of developing economic single cell protein products, that are suitable for human consumption, are described in chapter 3 here:
They've altered Fusarium venenatum which is currently what Quorn utilizes in its products.
"The production process of gene-edited MP is more environmentally friendly than chicken meat and cell-cultured meat."
That's good news, if they get to the point where it is more economically friendly than chicken meat it will be great news.
While the paper is behind a pay wall, the abstract highlights that they used knock out gene editing, meaning this is not a GMO of the old days, with trans genes, but a mkdifcation one could have achieved with classical breeding if given enough time and resources.
If I understand this right, this would even in the EU now be allowed to be sold without the GMO label.
I’m vegetarian. The "tastes like meat" claim is misleading. The main issue isn't the taste, it's the texture. Impossible Burger came close. Most mushroom-based substitutes I’ve tried are nothing like it.
I am never going to stop eating beef or poultry, no matter what any scientist or politician thinks about sustainability.
We have been using these as healthy, nutritious food sources for eons. I'm fine with people creating alternatives and making them available, but far too many people want to see the former disappear because they're misled by bad science and hysteria.
This sounds like they took a product that failed in the market - fungus based meat substitutes, and hinted at some superscience magic thats years from coming out, and that's if it proves safe, economical and a genunie improvement.
This really looks like an attempt to get investors to come back and push the stock price.
This! Would love if we spent some of that sweet AI money into engineered new food sources. I've been watching Soylent for a while now. Food that can be made in space is what we need for interplanetary travel. Qudos to this crispr research!
meet tastes great and all, but I wonder where science is at (if at all) on making original food that tastes good. How about food that doesn't taste like any natural food we've had, but still tastes really good?
Jell-o (gello?) is a good example, nothing tastes like it naturally. Why aren't there tasty food that are original in terms of taste and texture but good for health and the environment? I suppose part of the struggle is that food is entrenched into culture so much. burgers and bbq are inextricable from july 4th and memorial day for example.
"Chicken of the woods", Hen of the woods?, whatever, shelf fungus, grows on dieing hardwoods, often in huge quantities, cooks like chicken, looks like chicken, tastes like chicken, but costs more unless you can gather it yourself.It also lasts for weeks on top of the fridge, but there must be ways to keep it longer.
It's so odd to me as a veggie that people want something that "tastes like meat". If you've been immersed in decent veggie food for a while this isn't something you crave. Why would I want to eat a bit of dead animal? It's something I might do in a survival situation in a barren place, like Han Solo or something, but not if there are fresh veggies to hand.
If you want to do this for ethical reasons, which you should, then just eat vegetables. They taste way better. You just have to recalibrate your senses to deal with the higher levels of flavour.
But if people really want "chicken nuggets" for some reason then there's no reason it should have to involve animals at all, so this is a good thing, I guess.
I cant wait to see the unintended consequences. Imagine eating a food which then digests you from the inside out. Wait, wasnt there a video game like this?..,,,half-life
CRISPR fungus: Protein-packed, sustainable, and tastes like meat
(isaaa.org)305 points by rguiscard 12 December 2025 | 230 comments
Comments
The paper notes:
>It is important to note that MP products often contain elevated levels of nucleic acids, constituting ~8% of the dry weight [17], which necessitates consideration when assessing their suitability for human consumption. To address this, a heat treatment process is employed at the end of fermentation that reduces the nucleic acid content in the fermented biomass to below 0.75/100 g, while simultaneously deactivating protease activity and F. venenatum biomass. However, this procedure has been observed to induce cell membrane leakage and a substantial loss of biomass, as evidenced in the Quorn production process [17], which also utilizes F. venenatum as the MP producer. Our experimental trials have encountered similar challenges, achieving a biomass yield of merely ~35%, and observed that heating process increased the relative protein and chitin content (Figure 2D,E), which may be related to the effect of membrane leakage, while the intracellular protein of the FCPD engineered strain was less likely to be lost to the extracellular. Thus, concentrating the fermentation broth to enhance protein and amino acids content in successive steps to produce a highly nutritious water-soluble fertilizer appears to be an effective strategy for adding value to the process (Figure 1).
The challenges of developing economic single cell protein products, that are suitable for human consumption, are described in chapter 3 here:
https://www.researchgate.net/profile/Martin-Hofrichter-2/pub...
If I understand this right, this would even in the EU now be allowed to be sold without the GMO label.
"The first modification, eliminating a gene for chitin synthase, resulted in thinner fungal cell walls."
This also has an enormous potential benefit of reducing avian flu and other zoonotic bird diseases.
https://www.quorn.us/
We have been using these as healthy, nutritious food sources for eons. I'm fine with people creating alternatives and making them available, but far too many people want to see the former disappear because they're misled by bad science and hysteria.
This really looks like an attempt to get investors to come back and push the stock price.
Jell-o (gello?) is a good example, nothing tastes like it naturally. Why aren't there tasty food that are original in terms of taste and texture but good for health and the environment? I suppose part of the struggle is that food is entrenched into culture so much. burgers and bbq are inextricable from july 4th and memorial day for example.
This is a huge disadvantage. Not every farmer is a biological research institute.
Details are a bit vague but it seems like it's viable.
If you want to do this for ethical reasons, which you should, then just eat vegetables. They taste way better. You just have to recalibrate your senses to deal with the higher levels of flavour.
But if people really want "chicken nuggets" for some reason then there's no reason it should have to involve animals at all, so this is a good thing, I guess.